In Generative Grammar, English Long-distance questions (LDQs) are derived by way of moving wh-phrases successively, whereas in Construction Grammar, they are combinations of different constructions with compatible informational status. In the current L2 literature, both the location of wh-phrases (syntactic variants) and the information status of the embedded clauses are the possible factors that affect L2 acquisition of English long-distance questions. This study, on the basis of Generative L2 views and Construction L2 views, formulates predictions concerning L2 acquisition of 6 variants of English LDQs and verifies them by way of a standard empirical study. It is found in this study that the current L2 research is confined either to syntatic variant or to informational status (thereby leading to one-sidedness in their conclusions), whereas the major factor that affects the grammaticality of LDQs in the end-state interlanguage grammar is the two-way interaction between syntactic variant and informational status.