Wilhelm Gesenius was a renowned professor at the University of Halle in Germany and a specialist in various oriental languages. At the end of 1822, he happened to get acquainted with two young Cantonese sailors who were traveling in Germany. He came up with the idea of establishing Sinology as a scientific discipline in Germany with their assistance. Under the support of the Prussian authorities, the two Chinese were placed under the supervision of Gesenius, who paired them with two German doctors. The plan was for the Germans to learn Chinese and for the Chinese to learn German over the course of three years. Unfortunately, this experiment failed to produce the expected results. Nevertheless, it is regarded as the earliest verifiable attempt at mutual language instruction between Chinese and German, which is of cultural-historical significance. Based on primary archival sources, this paper examines the causes and effects of this relatively unknown historical event.